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Researchers observed that upon binding the IRR, ARA-290 initiates signaling through JAK2 and downstream pathways including STAT3 and NF-B modulation, distinct from the STAT5-dominant signaling of classical EPO receptor activation

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Aberrant recognition by specific immunoreceptors may occur in upstream pathways, which may subsequently contribute to downstream cytokine dysregulation, particularly in the IL-23/IL-17 axis

These studies contribute to the broader field of peptide drug development by informing best practices for improving the pharmacokinetic and physicochemical profiles of therapeutic peptides